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96HoldstockL, MeadowcroftAM, MaierR,

These medications increase dopamine and norepinephrine levels in the brain

The crossover study (Parsons et al., 2012) reported that at 12 hours after a single instillation, 50% of patients reported a successful response to the active instillation with a 42% reduction in pain but only 13% reported a successful response to the placebo instillation accompanied by a 21% reduction in pain