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The analysis of allele frequencies in candidate gene variants and SNPs holds significant implications for various scientific domains, including uncovering the genetic correlations with diseases and health-related traits, and estimating the prevalence of individuals predisposed to certain conditions or drug resistance within populations [47]

Importantly, these findings were later corroborated by in vivo studies where both acute (single high-dose striatal injection) and sub-chronic (21 days of 30 mg/kg intranasal Mn) exposure reduced GLAST/GLT-1 expression and were associated with motor deficits, at doses approximating human Mn exposure (Johnson et al., 2018