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In preclinical studies published in Endocrinology, researchers found that chronic administration of AOD-9604 reduced body weight and body fat in obese mice while increasing beta-3 adrenergic receptor expression to levels comparable with lean mice

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In casecontrol study, diabetic patients with peripheral neuropathy had lower serum zinc levels, and zinc levels were negatively correlated with HbA1c, neuropathy scores (NSC and MNSI), and nerve conduction [590]

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