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This makes it particularly relevant in clinical contexts where someone has gut lining compromise alongside systemic inflammation, for example, long-term NSAID use for chronic pain

doi: 10.3390/ijms21239201 152 JayarajRLBeiramRAzimullahSMfNMOjhaSKAdemAet al

Lee, HM, Saw, AK, Morris, VK, Napolitano, S, Bristow, C, Srinivasan, S, Peoples, M, Sorokin, A, Kanikarla Marie, P, Schulz, J, Singh, A, Terranova, C, Coker, O, Jain, A, Kopetz, S , Rai, K

Likewise, in mice treated with MPTP, which causes the degeneration of dopaminergic neurons, immunoprecipitation of aSyn and subsequent western-blot analysis indicated that aSyn was nitrated as early as 4 h following MPTP treatment 117