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In this work, whole blood cultures from moderate or severe COVID-19 patients were used to assess the potential of B12 as adjuvant drug

Oxidative stress is considered another pathogenic factor, as evidenced by elevated levels of malondialdehyde (MDA) and reduced activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in AA patients [34, 35]

During prolonged ER stress, IRE1, PERK, and ATF6 may induce pro-apoptotic signaling through activation of C/EBP homologous protein (CHOP), which subsequently leads to the initiation of ER stress-mediated apoptosis through regulation of Bcl-2 family members (Wongprayoon and Govitrapong (2017) suggested that METH-induced apoptotic death is mediated (at least in part) through an ER-dependent mechanism involving CHOP, spliced X-box binding protein 1 (XBP1), caspase-12, and caspase-3 in vitro

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