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Wang B, Yang LP, Zhang XZ, Huang SQ, Bartlam M, Zhou SF (2009) New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme

Between 1% and 10% of the lysate was retained as input control, and the remaining lysate was used for immunoprecipitation

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Accordingly, GGTs from eukaryotes and Gram-negative organisms have been termed as lid-loop positive and GGTs from Bacillus species, archaea, and extremophiles as lid-loop negative