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The output revealed that the binding of n-hexadecanoic acid with SIRT1 was encouraged by associations with LEU206, ILE223, and ILE227, which were hydrophobic

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Note that the co-existence of IBD and PSC is a distinct phenotype that differs from IBD alone [212] and that IBD within IBD-PSC is usually less severe than IBD alone, which could explain why IBD-PSC patients have a good response to mesalamine (a first-line drug for ulcerative colitis) for their IBD, when IBD is not too advanced [212]

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