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In our study, PI3K, mTOR, Beclin-1 and LC3 II/I expression were elevated in the cerebral I/R group, along with increased levels of apoptotic makers, caspase-3, Bax, decrease of Bcl-2 content, as well as downregulation of intact neurons number in both cortex and hippocampal CA1 region

Nature 450 , 725730 (2007)

Unlike a casual search, it follows strict protocols across multiple databases to ensure no important studies are missed a critical step before conducting a meta-analysis