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Polyamidoamine dendrimer microgels: hierarchical arrangement of dendrimers into micrometer domains with expanded structural features for programmable drug delivery and release

2005;128:A584

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Conclusions Abnormalities in sleep and circadian rhythms observed in psychiatric disorders can negatively affect the course of the disease

Interestingly, the correlation between the cAMP signaling efficacy obtained in vitro in cultured cells and the in vivo analgesic efficacy determined in living animals, for the 11-X-7OH series, suggests that the in vitro amplified system may mimic the receptor reserve and/or receptor-effector situation in the neurons of relevant pain circuitry, and thus provides a useful model system