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Cell Death Dis 10 , 321 (2019)

Certain types of cancer cells have observed that fenofibrate, a peroxisome proliferator-activated receptor agonist, induces mitochondrial dysfunction and promotes cancer cell death [538]

Epigenetic alteration 4

Together, these results indicate that both acidosis redirects cellular glutamine to the TCA cycle for cellular bioenergetics (ATP generation), which leads to depletion of other glutamine-dependent metabolites, such as GSH