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doi:10.1016/j.ipha.2024.09.008

The method for constructing the transmitochondrial cell model was performed as previously described [60]

The measurement of antioxidant index and myeloperoxidase activity in the lung homogenate Biochemical assays were carried out in the supernatants of homogenates of lung tissues and A549 cell samples

In addition, capsaicin (CAP), another gut microbiota metabolite, alleviates ventilator-induced lung injury by activating Sirtuin 3 (SIRT3) to inhibit ferroptosis and maintain mitochondrial redox homeostasis (129)

However, the study using incremental doses of APAP demonstrated that, although Il-6 was induced and Stat-3 was activated after a moderately toxic dose and a regenerating dose of APAP, activation of Il-6/Stat-3 signaling was even higher and sustained after a severely toxic dose of APAP, in which liver regeneration was impaired