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Despite this extra CBM loop, the absence of a loop ~15 residues in length that resides at the Loop 1 position may explain why Bu GUS, Bd GUS, and other non-L1 GUS enzymes exhibited higher K m values for p NPG compared to Ec GUS, Ee GUS, Sa GUS, and Cp GUS

10.1111/j.0954-6820.1968.tb02452.x 9 BolamanZ.KadikoyluG.YukselenV.YavasogluI.BarutcaS.SenturkT

Some individuals report: Gradual improvement in joint comfort Enhanced mobility and flexibility Support during recovery from physical strain Improved digestive comfort Increased resilience in connective tissues Results typically develop progressively with consistent use under professional supervision

doi: 10.1038/nature06005 3

1993;149(5 Pt 2):13191320