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Real time-PCR (RT-PCR) results revealed that peroxynitrite treatment caused significant increases in the mRNA expression of proapoptotic genes Bax and P53 , and decreases in the mRNA expression of antiapoptotic genes Bcl2 and Bcl-xL compared with controls (Figure 8D)

39 : 533541 Yamagata K, Tagami M, Ikeda K, Yamori Y and Nara Y (2000) Altered gene expressions during hypoxia and reoxygenation in cortical neurons isolated from stroke-prone spontaneously hypertensive rats

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Consequently, the quest for effective and highly selective GLS inhibitors remains an open question