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AMPK/ULK1 signaling pathway The AMPK/ULK1 pathway acts during the initiation of autophagy

Notably, so-called NRF2 activators primarily function as inhibitors of Keap1, the cytoplasmic repressor that targets NRF2 for proteasomal degradation (Magesh et al., 2012)

The resemblance of telomeres with DNA breaks requires the suppression of several DNA damage response (DDR) pathways that otherwise target double-strand (ds) DNA breaks and ssDNA, which make telomeres particularly susceptible to erroneous activation of the DDR and cell cycle arrest 4

Along these lines, estimates suggest that nearly half of the US population does not meet the recommended magnesium intake through diet alone