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For this purpose, specific markers of cellular elements that might be compromised during the genesis of the disease and cell proliferation markers were used

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When it binds MC1R on melanocytes, it triggers cyclic adenosine monophosphate (cAMP) signaling, which upregulates tyrosinase activity and accelerates melanogenesis (i.e

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25.9 Lentiginous junctional nevus: the rete ridges are elongated and increased numbers of melanocytes are present as nests at the tips of the rete ridges and single cells distributed along the sides