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NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism

These results support development of small molecule NNMT inhibitors as therapeutics to reverse diet-induced obesity and validate NNMT as a viable target to treat obesity and related metabolic conditions

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Semaglutide (Ozempic, Wegovy, Rybelsus) Semaglutide is a GLP-1 receptor agonist available under brand names such as Ozempic (for type 2 diabetes), Wegovy (for obesity), and Rybelsus (an oral form)