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10.1016/j.actbio.2014.01.020 Acta Biomater

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To account for possible selection bias, we used within-individual analyses (similar to prior studies on psychotropic drug use [11, 22, 23]) to adjust for confounders that remained constant within each patient during follow-up, including both observed confounders (e.g., demographics) and unobserved confounders that were not available in our data (e.g., genetic profile, intrinsic treatment adherence, illness severity)

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