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Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging

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[22] The NIH "Roadmap Epigenomics Project", which ran from 2008 to 2017, uses the following definition: "For purposes of this program, epigenetics refers to both heritable changes in gene activity and expression (in the progeny of cells or of individuals) and also stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable." [23] In 2008, a consensus definition of the epigenetic trait, a "stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence," was made at a Cold Spring Harbor meeting

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Since SNc neurons are, by definition, still spared from LBs in iLBD, investigating SNc neurons in these cases may provide insight into the cellular and molecular changes occurring at this critical site in the absence of LBP [71], thus allowing to distinguish LBP-dependent from LBP-independent changes