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The bigger question is whether it does enough for the cost, and what realistic expectations are

The most commonly accepted theory is that a defect in the glycosaminoglycan layer of the bladder urothelium allows solutes in the urine to penetrate through the urothelium into the bladder interstitium which causes an inflammatory reaction [1]

it is actively supporting the biological systems that keep you well

doi: 10.1016/S0378-3782(01)00211-0

The NewcastleOttawa Scale consists of three main assessment categories: Selection (adequate definition of cases, representativeness of cases, selection of controls, definition of controls), Comparability (control for important factor or additional factor), and Exposure (ascertainment of exposure, same method of ascertainment for cases and rate controls, Non-Response rate)