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Clinically, these mechanisms emphasize the potential value of combining DOX with autophagy inhibitors, lysosomal function modulators, or regulators of lipid raft integrity to overcome resistance

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The findings from the comparison of growth phase dates indicated that the peak values for glutathione, proline, and carotene were 71.238, 22.359, and 1.625 mg.l -1 respectively during the second growth phase

Future multi-center clinical trials that incorporate various imaging modalities and stratify participants by various factors, such as age of onset and disease stage, will provide a more comprehensive understanding of FRDA and contribute to the development of new therapies