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Discussion Sex and gender disparities exist in bladder cancer, where men have a four times higher incidence rate, and women have significantly higher rates of high-grade disease and a lower 5-year survival rate

From a mechanistic perspective, evidence shows that NMN treatment upregulates SIRT1 expression, regulates the MSCs in aging bone marrow through the SIRT1 pathway, and thus promotes bone formation and reduces adipogenesis [49]

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Another key factor is less intrinsic factor production

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