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Unlike IV infusion, subcutaneous administration eliminates the flushing, nausea, and chest tightness that IV protocols can produce when infused too rapidly

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While it is not clear how this translates to the kinetics of cAMP production in cells expressing individual receptors, the divergence in peptide responses across each receptor is consistent with the dynamic conformational differences that were observed structurally for individual AMYRs bound to distinct peptides

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