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The high and middle dose groups exhibited clearer alveolar structures, reduced collagen protein levels, and improved PF, while the low dose group showed evident PF and collagen deposition

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This pulsatile pattern is considered more physiologically appropriate than continuous GH elevation, and is preserved across multiple administration cycles

1.2 Rationale for immune monitoring The immune system is a dynamic and complex network in which numerous cellular and molecular interactions occur simultaneously in a context that is both spatially and temporally regulated (56)