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For example, it appears to switch cardiomyocyte energy production from glucose utilization to fatty acid oxidation in mice, dependent on UCP2 induction (282)

Disruption of the NKG2A:HLA-E immune checkpoint axis to enhance NK cell activation against cancer

As such, preserving circadian integrity emerges as a strategic target in precision geromedicine, not only to mitigate systemic aging but also to tailor pharmacological treatments