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Other conditions such as POTS (Postural Orthostatic Tachycardia Syndrome heart rate increases when standing up, often manifesting as fainting or dizziness), blood pressure changes (often related to dysautonomia issues), MCAD (Mast Cell Activation Disorder sometimes severe and unusual allergy symptoms) are commonly associated with EDS, but are not definitive for diagnosis

Studies have shown that when stem cells are co-cultured in an IDD-like environment in vivo or in vitro, they can produce anti-inflammatory cytokines, anti-metabolic mediators, and growth factors, thus modulating the immune response [33,34,35] (Fig

De Oliveira DP, Garcia EF, De Oliveira MA, Candido LCM, Coelho FM, Costa VV, et al

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