methionine restriction glutathione

methionine restriction glutathione Main effects of the biological activity of the Met and Methionine restriction promotes cGAS activation

Name: methionine restriction glutathione Main effects of the biological activity of the Met and Methionine restriction promotes cGAS activation
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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity: Cancer Cell Dietary cystine restriction increases the proliferative capacity of the small intestine of mice PLOS One Methionine restriction and mimetics to ameliorate human aging and disease: Trends in Endocrinology & Metabolism Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication PMC Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism Nature Communications

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The primary efficacy endpoint is the 90-day overall survival

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The compound of 6 is halogen, hydroxy, CN, C 1-3 alkyl, C 1-3 haloalkyl, C 3-6 cycloalkyl, OC 1-3 alkyl, OC 1-3 haloalkyl, OC 3-6 cycloalkyl, S(O) 2 C 1-3 alkyl, S(O) 2 NHC 1-3 alkyl, C(O)NHC 1-3 alkyl, C 1-6 alkylNR 11 R 11 , or 5 membered heteroaryl with 2 N atoms, and wherein the cycloalkyl is optionally substituted with halogen