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By detecting the appearance of the colored quinones on a TECAN infinite M200 absorption curves were recorded at different substrate molarities in a total volume of 200 l containing 50 mM sodium phosphate buffer at pH 6.0, 2 mM SDS and variable amounts of enzyme (Table S7) at 25 C

Functional mtDNA mutations that impair oxidative phosphorylation and reduce ATP production markedly weaken the ability of cells to maintain energy homeostasis through endogenous mitochondria, thereby increasing their metabolic dependence on exogenous functional mitochondria [372]

As reported by the authors, administration of 50 mg/kg/alternate day of curcumin in conjuction with Al 3+ (100 mg/kg/day) for a period of 8 weeks significantly normalized the altered activities of mitochondrial complexes and reduced the levels of glutathione in rat brain

10.1021/acsnano.4c15283 121

H2O2 selfproducing singleatom nanozyme hydrogels as lightcontrolled oxidative stress amplifier for enhanced synergistic therapy by transforming cold tumors