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FIGURE 2 This figure depicts the dysregulation of the HPA axis in PTSD, highlighting the altered cortisol secretion patterns due to impaired negative feedback

endothelial NOS, neural NOS, and iNOS) exerts different effects on -cell function [48], and in most cases, the eNOS/nNOS-derived NO has physiological relevance, whereas iNOS-derived NO in general has pathological effects

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According to reports, every 30 s in the world, one diabetic patient suffers from amputation due to persistent diabetic chronic ulcers, and the annual cost of medical costs and lots of productivity due to diabetic wounds is more than 200 billion US dollars (Al-Mohaithef et al., 2022)

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