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Shewale JB, Correa AM, Brown EL, Leon-Novelo LG, Nyitray AG, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Walsh GL, Roth J, Vaporciyan AA, Swisher SG , Sepesi B

As described above for PABA/NO, JS-K, and GSNO, the NHGs, in accordance with GT expression patterns, contribute to chemotherapy by producing locally high levels of NO which can rapidly react with O 2 - to generate the potent oxidant peroxynitrite that, in turn causes extensive cellular damage, including the nitration of protein tyrosine residues (Kirsch et al., 2001)

As a result, metabolite 13 C-labelling ratios offer a more practical readout for assessing relative excitatoryinhibitory metabolic balance in vivo

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