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Integration with iPSC-derived human microglia and in vivo models will be critical to validate mechanisms and enhance translational relevance

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Probiotics also increase the synthesis of proteins that constitute the TJ

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Based on the rat study data, much lower doses (scaling from 0.5 micrograms per kilogram) may also be effective

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HepG2 cells were obtained from European Collection of Cell Cultures (ECACC, Salisbury, United Kingdom)

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Guidelines for reducing overall cancer risk are discussed on pages 201

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