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These research results indicate that lactylation has potential as a treatment target for sepsis-induced injury

Conversely, the downregulation of the antioxidant system following manganese exposure results in the inhibited activity of (i) antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) and (ii) protein inhibition involved in the synthesis of GSH

These findings have implications for dilated cardiomyopathy research, post-infarction remodeling studies, and investigations into preventing adverse cardiac remodeling that leads to chronic heart failure

doi: 10.1177/0148607113495414 [DOI] [PMC free article] [PubMed] [Google Scholar] 43

The Importance of Glutathione Antioxidant Defense : Glutathione protects cells from oxidative damage by neutralizing free radicals and reactive oxygen species (ROS)