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METABOLISM OF VITAMIN B12 4

8.8 Animal Studies 8.8.1 In Vitro Studies In studies involving the addition of various aminophenols such as 2-aminophenol, 2-amino-4-chlorophenol, 2-amino-4,6- dichlorophenol, 2-amino-5-ethoxyphenol, 2-dimethylaminophenol, 4-aminophenol, 4-methylaminophenol, and 4-dimethylaminophenol to the blood of mice, cats, dogs, cattle, and man, it has been shown that 4-dimethylaminophenol and 4-methylaminophenol produce consistent amounts of methaemoglobin most rapidly

92 In COPD patients, TGF- promotes a fibrotic airway remodelling, which can further contribute to a diminished lung function

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Again, these effects are temporary and generally mild