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Studies in humans and animals with non-alcoholic fatty liver disease show that CD44 plays a key role in the inflammation and liver damage in NAFLD.[ref] Other genetic studies have looked at genes in pathways known to be involved in acetaminophen metabolism, including genes related to sulfation, glucuronidation, and glutathione production

In a study conducted by Wu and et al

KaramaliMNourgostarSZamaniAVahedpoorZAsemiZ.The favourable effects of long-term selenium supplementation on regression of cervical tissues and metabolic profiles of patients with cervical intraepithelial neoplasia: a randomised, double-blind, placebo-controlled trial

With age, WAT/body weight ratios increased in WT mice (0.8 +/- 0.1% young, 4.1 +/- 0.3% old) and Has1,3 dko mice (0.8 +/- 0.01% young, 2.3 +/- 0.2% old) but this increase was 44% less in old Has1,3 dko mice