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The invasive nature of laparoscopy introduces risks and delays that may not be justified for a benign condition

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For placebo, the overall biochemical response rate was 3.8% and only occurred in patients with a baseline ALP 2xULN ( Figure 1A )

All of these processes provoke endothelial dysfunction, platelet aggregation, and metalloproteinase expression and favor thrombogenesis (Esper et al., 2006)