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Notably, the activation of iron-regulated inflammasomes ultimately leads to oxidative stress and ferroptosis in RPECs (241)

Regulation of GCL modifier subunit (GCLM) As stated above, the light subunit of GCL plays a critical regulatory role on the overall function of the enzyme (Huang et al., 1993a

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[141] Renal impairment typically does not require dose adjustments for ondansetron, as the drug is primarily eliminated through hepatic metabolism rather than renal excretion