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f-j , Volcano plot of metabolic differences ( f) and levels of GSSG (g) , ophthalmic acid (h) , glutamate (i) , cysteine (NEM-cysteine) (j) from Gclc WT and Gclc KO tumors

Selective delivery to the lymph is largely dictated by size, as macromolecules or particulate carriers are excluded from access to blood capillaries, whereas interstitial fluid flow sweeps larger constructs into the more permeable lymphatics

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In contrast to their protein-bound counterpart, FAAs can interact with specific receptors present on a wide variety of cells in various parts of the body, including the intestines, where they can activate specific intracellular pathways and confer physiological effects (34, 48)