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Nevertheless, while getting enough vitamin A is vital, too much may cause harm

doi: 10.3390/biomedicines13020352 60

10.3969/j.issn.1672-3619.2021.03.002 211 ZhaoL

This mitochondrial respiratory enhancement under oxidative stress conditions is proposed as a primary mechanism of DSIPs stress-protective and neuroprotective potency and connects DSIP biology to the broader field of mitochondria-targeted neuropeptide research

To address the reactivities of the redox-sensitive cysteinyl residues, we also analyzed the recombinant monothiol roGFP2 variants roGFP2 C151S and roGFP2 C208S and detected small but reproducible glutathionylation-dependent changes of fluorescence at both excitation wavelengths for roGFP2 C151S (SSG) and roGFP2 C208S (SSG) (Fig