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This was in confirmation of our earlier studies on different diabetic rat models ( At the center of the cellular response to oxidative stress is the keap 1-Nrf2-antioxidant response elements (ARE) pathway, which helps in the maintenance of cellular homeostasis and detoxification by regulating the expression of many antioxidant proteins (Yoh et al., 2008)

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Recent studies suggested that one of the enzymes inhibited by auranofin is GSTP1-1 (Fig

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Sleep problems, again, tend to have a negative effect on appetite