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Spine loss and other dendritic abnormalities in epilepsy

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Although initially suggested to act via recruiting HDAC3, Xist-mediated silencing is abolished by SHARP deletion, but only attenuated upon HDAC3 deletion 48,49 , suggesting that additional mechanisms are involved in SHARP-dependent repression of the X-chromosome

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A 2014 in vitro study on brain cortex cells demonstrated that Pinealon stimulates serotonin expression, the neurotransmitter that serves as the direct precursor to melatonin