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GOT2 silencing promotes reprogramming of glutamine metabolism and sensitizes hepatocellular carcinoma to glutaminase inhibitors

10.1056/NEJMra1905136 48 de FreitasL

Elesclomol, however, can abrogate these changes, indicating the regulatory role of the PI3K/mTOR pathway in ferroptosis and cuproptosis, particularly in cuproptosis (Li Z

Currently, multiple drugs have been identified to stimulate ferroptosis, classified into four categories according to their ability to inhibit the Xc-system and GSH, directly inhibit GPX-4, reduce GPX-4 and CoQ10 protein, and induce lipid peroxidation [51]

KEGG pathway analysis suggested that the mechanisms through which DP may prevent and treat DFU involve the AGE-RAGE signaling pathway, lipid metabolism and atherosclerosis pathways, and ROS regulation (Fig