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Multiple studies have reported increased adenosine levels in the CSF of ALS patients [431], along with increased adenosine A 2A receptors expression in their lymphocytes [432]

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Observations from the 1980s showing that light increases the rate of nonenzymatic PLP catalyzed decarboxylation, possibly increases enzymatic decarboxylation of DOPA, and promotes quinonoid formation in AAT sparked our interest in probing the enhancement of AAT activity by light.[8284] Our first publication in this area examined changes in spectroscopic properties on the femtosecond to minute time scale of PLP in aqueous solution as well as Schiff bases with valine and aminoisobutyrate.[85] It was found that free PLP and the Schiff bases convert from an excited singlet state to a triplet state on the s time scale and that the charge structure of the triplet state leads to rapid loss of a proton to form the carbanionic intermediate with valine

Based on standard QTAIM criteria, these values indicate that the main force between C 60 and GHB is through dispersion forces and not traditional covalent bonding

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