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[DOI] [PubMed] [Google Scholar] [17].Conrad M, Moreno SG, Sinowatz F, et al

Upon oxidative stress, sudden MPT causes massive ion influx that dissipates mitochondrial membrane potential and shuts down OXPHOS, ATP production and ROS overgeneration

A systematic review of 63 studies confirmed that elevated GDF-15 is an independent predictor of all-cause and cardiovascular mortality, hospitalization, renal dysfunction, and major adverse cardiac events, mainly in patients with HF and atrial fibrillation (145)