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Research demonstrates that NNMT expression increases significantly with advancing age, particularly in metabolic tissues, contributing to the progressive decline in NAD+ levels observed during aging

Although this area of study is still emerging, it highlights potential new directions for understanding NNMTs role in adipose biology

It is also vital for fetal development and other bodily functions

Real-world data from clinics offering this combination protocol suggests enhanced fat loss compared to tirzepatide alone, but these observations come from uncontrolled clinical settings and cannot substitute for randomized controlled trials