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[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Bettermann E.L., Hartman T.J., Easley K.A., Ferranti E.P., Jones D.P., Quyyumi A.A., Vaccarino V., Ziegler T.R., Alvarez J.A

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Reported adverse reactions include nausea, difficulty breathing, and, in rare cases, serious conditions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and renal dysfunction

Toxicology 393:171184 Robles M, Aregullin M, West J, Rodriguez E (1995) Recent studies on the zoopharmacognosy, pharmacology and neurotoxicology of sesquiterpene lactones

With those who are highly motivated, significant improvements can be seen within the first couple of months of treatment