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Part of this migratory effect can be attributed to the stimulation of IL-1 secretion by resident macrophages via MSU crystals, which subsequently instigates caspase-11 expression in macrophages through IL-1R and MYD88 ( sUA triggers macrophage migration indirectly

Nature 2021, 599:136140

Vinorelbine (navelbine): A third-generation vinca alkaloid

While the specific mechanisms underlying asthma have yet to be identified, there is accumulating evidence that oxidative stress from altered GSH/GSSG redox status may play an important role in the modulation and severity of the disorder