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Exploiting the computational algorithm, convergent motifs for binding sites (COMBS) for designing a small-molecule binding protein, Dang, DeGrado, and coworkers prepared a highly specific de novo protein, Apixaban binding helical bundle ( ABLE ) and PARP inhibitor binder ( PiB ) proteins for the rapid clearance of the achiral antithrombotic drug apixaban and the anticancer drug rucaparib , respectively (Fig

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The substance is naturally occurring in the body, reducing the risk of adverse reactions