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Modification of the ethyl chain and the introduction of a benzylic moiety on the aromatic amine produced derivatives such as SRS11-92 (EC50 = 6 nM), which demonstrated significantly enhanced potency

In this regard, hydrogen peroxide is converted into the hydroxyl radical, a harmful and highly reactive ROS, in the presence of transition metals such as iron (Figure 1)

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52 In addition, most cancer cells are extremely vulnerable to glucose withdrawal, 53, 54, 55, 56, 57, 58, 59 a feature they owe to metabolic reprogramming, leading to constitutively active proliferation pathways and glucose addiction