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In clinical research, that effect is often reflected through body weight reduction and waist circumference change over defined protocol windows, and those endpoints are exactly what the phase 2 cagrilintide trial reported

Participants in the highest dose group (4.5mg weekly) achieved a mean body weight reduction of approximately 10.8% from baseline, compared to around 3% in the placebo group

doi: 10.3390/jcm4040715 85 ZhangQJiaJHeLFanYWangN

While it is popular in wellness and performance communities, human evidence remains limited, and it should only be used under medical supervision

CagriSema still shows substantial, clinically meaningful weight loss, and the GLP-1 + amylin combination remains a highly interesting biological strategy