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From the ER, active STING travels to the Golgi apparatus, where it recruits and activates signaling molecules downstream, including IRF3 and TBK1

Second, FIN56 binds to the enzyme squalene synthase, which leads to the depletion of endogenous antioxidant coenzyme Q10 (COQ10)

The high recurrence rate in susceptible individuals makes treatment challenging 3 , with one of the strongest risk factors for developing a UTI being a previous UTI 2

Junqiang Xue, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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