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However, when combined with GnRH (Gonadotropin-Releasing Hormone) pulses and TRH (Thyrotropin-Releasing Hormone) infusion, it has been shown to significantly increase testosterone levels, with a peak increase of up to 312% observed in UK studies

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Figure 2B), supportive of intracellular compensatory mechanisms that mirror the ex vivo (BAL and fresh HAEC) findings